Table S6. KEGG pathway analysis of the differentially expressed genes in the Race15-LN vs. Race15-CK group class_A class_B Term Database ID Input number Background number P-Value Corrected P-Value Input Hyperlink Metabolism Carbohydrate metabolism Starch and sucrose metabolism KEGG PATHWAY ko00500 4 60 0.008320215 0.296185445 A00517|A09232|A10282|A03357 http://www.genome.jp/kegg-bin/show_pathway?ko00500/K01179%09red/K01176%09red/K01225%09red Organismal Systems Endocrine system GnRH signaling pathway KEGG PATHWAY ko04912 2 11 0.01129244 0.296185445 A11394|A05290 http://www.genome.jp/kegg-bin/show_pathway?ko04912/K07827%09red/K01115%09red Metabolism Lipid metabolism Fatty acid elongation KEGG PATHWAY ko00062 2 13 0.014958341 0.296185445 A10337|A08688 http://www.genome.jp/kegg-bin/show_pathway?ko00062/K07512%09red/K10703%09red Metabolism Xenobiotics biodegradation and metabolism Styrene degradation KEGG PATHWAY ko00643 2 15 0.019065396 0.296185445 A08689|A08690 http://www.genome.jp/kegg-bin/show_pathway?ko00643/K01426%09red Environmental Information Processing Signal transduction Phospholipase D signaling pathway KEGG PATHWAY ko04072 2 15 0.019065396 0.296185445 A11394|A05290 http://www.genome.jp/kegg-bin/show_pathway?ko04072/K07827%09red/K01115%09red Metabolism Amino acid metabolism Tryptophan metabolism KEGG PATHWAY ko00380 3 44 0.021115692 0.296185445 A07273|A08689|A08690 http://www.genome.jp/kegg-bin/show_pathway?ko00380/K03781%09red/K01426%09red Organismal Systems Endocrine system Melanogenesis KEGG PATHWAY ko04916 2 16 0.021276943 0.296185445 A11394|A11519 http://www.genome.jp/kegg-bin/show_pathway?ko04916/K07827%09red/K00505%09red Environmental Information Processing Signal transduction FoxO signaling pathway KEGG PATHWAY ko04068 2 17 0.023589991 0.296185445 A07273|A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04068/K03781%09red/K07827%09red Environmental Information Processing Signal transduction Ras signaling pathway KEGG PATHWAY ko04014 2 20 0.031110235 0.297349186 A11394|A05290 http://www.genome.jp/kegg-bin/show_pathway?ko04014/K07827%09red/K01115%09red Organismal Systems Aging Longevity regulating pathway KEGG PATHWAY ko04211 2 22 0.036580977 0.297349186 A07273|A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04211/K03781%09red/K07827%09red Environmental Information Processing Signal transduction Sphingolipid signaling pathway KEGG PATHWAY ko04071 2 25 0.045421195 0.297349186 A11394|A05290 http://www.genome.jp/kegg-bin/show_pathway?ko04071/K07827%09red/K01115%09red Metabolism Xenobiotics biodegradation and metabolism Aminobenzoate degradation KEGG PATHWAY ko00627 2 25 0.045421195 0.297349186 A08689|A08690 http://www.genome.jp/kegg-bin/show_pathway?ko00627/K01426%09red Cellular Processes Transport and catabolism Lysosome KEGG PATHWAY ko04142 2 29 0.058289158 0.297349186 A07168|A09856 http://www.genome.jp/kegg-bin/show_pathway?ko04142/K01201%09red/K01279%09red Metabolism Amino acid metabolism Phenylalanine metabolism KEGG PATHWAY ko00360 2 32 0.06867013 0.297349186 A08689|A08690 http://www.genome.jp/kegg-bin/show_pathway?ko00360/K01426%09red Cellular Processes Cellular community - eukaryotes Signaling pathways regulating pluripotency of stem cells KEGG PATHWAY ko04550 1 5 0.074008795 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04550/K07827%09red Organismal Systems Excretory system Aldosterone-regulated sodium reabsorption KEGG PATHWAY ko04960 1 5 0.074008795 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04960/K07827%09red Metabolism Amino acid metabolism Arginine and proline metabolism KEGG PATHWAY ko00330 2 35 0.079611838 0.297349186 A08689|A08690 http://www.genome.jp/kegg-bin/show_pathway?ko00330/K01426%09red Metabolism Global and overview maps Fatty acid metabolism KEGG PATHWAY ko01212 2 36 0.083374108 0.297349186 A10337|A08688 http://www.genome.jp/kegg-bin/show_pathway?ko01212/K07512%09red/K10703%09red Organismal Systems Nervous system Cholinergic synapse KEGG PATHWAY ko04725 1 6 0.085811696 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04725/K07827%09red Organismal Systems Endocrine system Prolactin signaling pathway KEGG PATHWAY ko04917 1 6 0.085811696 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04917/K07827%09red Environmental Information Processing Signal transduction ErbB signaling pathway KEGG PATHWAY ko04012 1 7 0.097467531 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04012/K07827%09red Organismal Systems Excretory system Endocrine and other factor-regulated calcium reabsorption KEGG PATHWAY ko04961 1 7 0.097467531 0.297349186 A11103 http://www.genome.jp/kegg-bin/show_pathway?ko04961/K11827%09red Organismal Systems Immune system B cell receptor signaling pathway KEGG PATHWAY ko04662 1 7 0.097467531 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04662/K07827%09red Organismal Systems Immune system Natural killer cell mediated cytotoxicity KEGG PATHWAY ko04650 1 8 0.10897809 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04650/K07827%09red Organismal Systems Nervous system Long-term potentiation KEGG PATHWAY ko04720 1 8 0.10897809 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04720/K07827%09red Cellular Processes Cellular community - eukaryotes Gap junction KEGG PATHWAY ko04540 1 8 0.10897809 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04540/K07827%09red Organismal Systems Nervous system Long-term depression KEGG PATHWAY ko04730 1 8 0.10897809 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04730/K07827%09red Organismal Systems Immune system Fc epsilon RI signaling pathway KEGG PATHWAY ko04664 1 8 0.10897809 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04664/K07827%09red Metabolism Amino acid metabolism Tyrosine metabolism KEGG PATHWAY ko00350 2 44 0.11526855 0.297349186 A11089|A11519 http://www.genome.jp/kegg-bin/show_pathway?ko00350/K13953%09red/K00505%09red Metabolism Glycan biosynthesis and metabolism Other glycan degradation KEGG PATHWAY ko00511 1 9 0.120345142 0.297349186 A07168 http://www.genome.jp/kegg-bin/show_pathway?ko00511/K01201%09red Organismal Systems Nervous system Serotonergic synapse KEGG PATHWAY ko04726 1 9 0.120345142 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04726/K07827%09red Organismal Systems Endocrine system Estrogen signaling pathway KEGG PATHWAY ko04915 1 10 0.131570436 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04915/K07827%09red Metabolism Biosynthesis of other secondary metabolites Betalain biosynthesis KEGG PATHWAY ko00965 1 10 0.131570436 0.297349186 A11519 http://www.genome.jp/kegg-bin/show_pathway?ko00965/K00505%09red Organismal Systems Digestive system Carbohydrate digestion and absorption KEGG PATHWAY ko04973 1 10 0.131570436 0.297349186 A03357 http://www.genome.jp/kegg-bin/show_pathway?ko04973/K01176%09red Environmental Information Processing Signal transduction VEGF signaling pathway KEGG PATHWAY ko04370 1 10 0.131570436 0.297349186 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04370/K07827%09red Metabolism Metabolism of cofactors and vitamins Retinol metabolism KEGG PATHWAY ko00830 1 10 0.131570436 0.297349186 A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00830/K13953%09red Organismal Systems Immune system T cell receptor signaling pathway KEGG PATHWAY ko04660 1 11 0.142655699 0.304152717 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04660/K07827%09red Organismal Systems Nervous system Glutamatergic synapse KEGG PATHWAY ko04724 1 12 0.153602637 0.304384216 A05290 http://www.genome.jp/kegg-bin/show_pathway?ko04724/K01115%09red Organismal Systems Immune system Chemokine signaling pathway KEGG PATHWAY ko04062 1 12 0.153602637 0.304384216 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04062/K07827%09red Environmental Information Processing Signal transduction Rap1 signaling pathway KEGG PATHWAY ko04015 1 12 0.153602637 0.304384216 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04015/K07827%09red Cellular Processes Cellular community - prokaryotes Quorum sensing KEGG PATHWAY ko02024 1 13 0.164412937 0.304384216 A10597 http://www.genome.jp/kegg-bin/show_pathway?ko02024/K01728%09red Cellular Processes Cell growth and death Apoptosis KEGG PATHWAY ko04210 1 13 0.164412937 0.304384216 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04210/K07827%09red Organismal Systems Development Axon guidance KEGG PATHWAY ko04360 1 13 0.164412937 0.304384216 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04360/K07827%09red Organismal Systems Nervous system Neurotrophin signaling pathway KEGG PATHWAY ko04722 1 13 0.164412937 0.304384216 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04722/K07827%09red Metabolism Lipid metabolism Ether lipid metabolism KEGG PATHWAY ko00565 1 13 0.164412937 0.304384216 A05290 http://www.genome.jp/kegg-bin/show_pathway?ko00565/K01115%09red Environmental Information Processing Signal transduction cAMP signaling pathway KEGG PATHWAY ko04024 1 14 0.175088266 0.304384216 A05290 http://www.genome.jp/kegg-bin/show_pathway?ko04024/K01115%09red Genetic Information Processing "Folding, sorting and degradation" SNARE interactions in vesicular transport KEGG PATHWAY ko04130 1 14 0.175088266 0.304384216 A02564 http://www.genome.jp/kegg-bin/show_pathway?ko04130/K08502%09red Organismal Systems Endocrine system Thyroid hormone signaling pathway KEGG PATHWAY ko04919 1 16 0.196040573 0.310856652 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04919/K07827%09red Metabolism Metabolism of cofactors and vitamins Riboflavin metabolism KEGG PATHWAY ko00740 1 16 0.196040573 0.310856652 A11519 http://www.genome.jp/kegg-bin/show_pathway?ko00740/K00505%09red Environmental Information Processing Signal transduction MAPK signaling pathway KEGG PATHWAY ko04010 1 16 0.196040573 0.310856652 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04010/K07827%09red Organismal Systems Endocrine system Progesterone-mediated oocyte maturation KEGG PATHWAY ko04914 1 16 0.196040573 0.310856652 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04914/K07827%09red Cellular Processes Transport and catabolism Endocytosis KEGG PATHWAY ko04144 2 64 0.20457473 0.310856652 A11103|A05290 http://www.genome.jp/kegg-bin/show_pathway?ko04144/K11827%09red/K01115%09red Metabolism Xenobiotics biodegradation and metabolism Chloroalkane and chloroalkene degradation KEGG PATHWAY ko00625 1 17 0.206320787 0.310856652 A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00625/K13953%09red Organismal Systems Endocrine system Oxytocin signaling pathway KEGG PATHWAY ko04921 1 17 0.206320787 0.310856652 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04921/K07827%09red Cellular Processes Cellular community - eukaryotes Tight junction KEGG PATHWAY ko04530 1 19 0.226497275 0.325766143 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04530/K07827%09red Organismal Systems Immune system Fc gamma R-mediated phagocytosis KEGG PATHWAY ko04666 1 19 0.226497275 0.325766143 A05290 http://www.genome.jp/kegg-bin/show_pathway?ko04666/K01115%09red Cellular Processes Transport and catabolism Peroxisome KEGG PATHWAY ko04146 2 69 0.228100015 0.325766143 A01284|A07273 http://www.genome.jp/kegg-bin/show_pathway?ko04146/K03781%09red/K11187%09red Metabolism Carbohydrate metabolism Propanoate metabolism KEGG PATHWAY ko00640 1 20 0.23639667 0.325766143 A06768 http://www.genome.jp/kegg-bin/show_pathway?ko00640/K18369%09red Metabolism Lipid metabolism Biosynthesis of unsaturated fatty acids KEGG PATHWAY ko01040 1 20 0.23639667 0.325766143 A10337 http://www.genome.jp/kegg-bin/show_pathway?ko01040/K10703%09red Metabolism Biosynthesis of other secondary metabolites Isoquinoline alkaloid biosynthesis KEGG PATHWAY ko00950 1 21 0.246172215 0.335150124 A11519 http://www.genome.jp/kegg-bin/show_pathway?ko00950/K00505%09red Environmental Information Processing Signal transduction Two-component system KEGG PATHWAY ko02020 1 22 0.255825423 0.336142707 A09101 http://www.genome.jp/kegg-bin/show_pathway?ko02020/K11231%09red Cellular Processes Cell motility Regulation of actin cytoskeleton KEGG PATHWAY ko04810 1 22 0.255825423 0.336142707 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04810/K07827%09red Metabolism Amino acid metabolism "Valine, leucine and isoleucine biosynthesis" KEGG PATHWAY ko00290 1 22 0.255825423 0.336142707 A10441 http://www.genome.jp/kegg-bin/show_pathway?ko00290/K17989%09red Organismal Systems Endocrine system Insulin signaling pathway KEGG PATHWAY ko04910 1 23 0.26535779 0.341198898 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04910/K07827%09red Metabolism Lipid metabolism Sphingolipid metabolism KEGG PATHWAY ko00600 1 24 0.274770794 0.341198898 A07168 http://www.genome.jp/kegg-bin/show_pathway?ko00600/K01201%09red Metabolism Carbohydrate metabolism Pentose and glucuronate interconversions KEGG PATHWAY ko00040 1 24 0.274770794 0.341198898 A10597 http://www.genome.jp/kegg-bin/show_pathway?ko00040/K01728%09red Organismal Systems Nervous system Synaptic vesicle cycle KEGG PATHWAY ko04721 1 24 0.274770794 0.341198898 A11103 http://www.genome.jp/kegg-bin/show_pathway?ko04721/K11827%09red Metabolism Xenobiotics biodegradation and metabolism Naphthalene degradation KEGG PATHWAY ko00626 1 25 0.284065896 0.348907025 A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00626/K13953%09red Metabolism Xenobiotics biodegradation and metabolism Drug metabolism - cytochrome P450 KEGG PATHWAY ko00982 1 26 0.293244539 0.352517371 A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00982/K13953%09red Environmental Information Processing Signal transduction PI3K-Akt signaling pathway KEGG PATHWAY ko04151 1 26 0.293244539 0.352517371 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04151/K07827%09red Metabolism Xenobiotics biodegradation and metabolism Metabolism of xenobiotics by cytochrome P450 KEGG PATHWAY ko00980 1 27 0.302308147 0.359587585 A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00980/K13953%09red Metabolism Lipid metabolism Fatty acid degradation KEGG PATHWAY ko00071 1 32 0.345949394 0.398900832 A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00071/K13953%09red Metabolism Carbohydrate metabolism Glyoxylate and dicarboxylate metabolism KEGG PATHWAY ko00630 1 33 0.354351796 0.404462151 A07273 http://www.genome.jp/kegg-bin/show_pathway?ko00630/K03781%09red Metabolism Global and overview maps Degradation of aromatic compounds KEGG PATHWAY ko01220 1 35 0.370841332 0.419050705 A11089 http://www.genome.jp/kegg-bin/show_pathway?ko01220/K13953%09red Environmental Information Processing Signal transduction mTOR signaling pathway KEGG PATHWAY ko04150 1 38 0.394806656 0.437383845 A11394 http://www.genome.jp/kegg-bin/show_pathway?ko04150/K07827%09red Metabolism Amino acid metabolism Cysteine and methionine metabolism KEGG PATHWAY ko00270 1 42 0.425377132 0.462188615 A10441 http://www.genome.jp/kegg-bin/show_pathway?ko00270/K17989%09red Metabolism Global and overview maps Carbon metabolism KEGG PATHWAY ko01200 2 114 0.437818213 0.464769156 A07273|A10441 http://www.genome.jp/kegg-bin/show_pathway?ko01200/K03781%09red/K17989%09red Metabolism Carbohydrate metabolism Glycolysis / Gluconeogenesis KEGG PATHWAY ko00010 1 44 0.440091148 0.464769156 A11089 http://www.genome.jp/kegg-bin/show_pathway?ko00010/K13953%09red Metabolism Lipid metabolism Glycerophospholipid metabolism KEGG PATHWAY ko00564 1 44 0.440091148 0.464769156 A05290 http://www.genome.jp/kegg-bin/show_pathway?ko00564/K01115%09red Metabolism Carbohydrate metabolism Amino sugar and nucleotide sugar metabolism KEGG PATHWAY ko00520 1 45 0.447309428 0.468018197 A03681 http://www.genome.jp/kegg-bin/show_pathway?ko00520/K01183%09red Metabolism Amino acid metabolism "Glycine, serine and threonine metabolism" KEGG PATHWAY ko00260 1 53 0.501873197 0.515560648 A10441 http://www.genome.jp/kegg-bin/show_pathway?ko00260/K17989%09red Genetic Information Processing "Folding, sorting and degradation" Protein processing in endoplasmic reticulum KEGG PATHWAY ko04141 1 77 0.635858596 0.641535904 A08743 http://www.genome.jp/kegg-bin/show_pathway?ko04141/K08288%09red Metabolism Global and overview maps Biosynthesis of amino acids KEGG PATHWAY ko01230 1 125 0.806719244 0.806719244 A10441 http://www.genome.jp/kegg-bin/show_pathway?ko01230/K17989%09red